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KMID : 0370220100540050334
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Yakhak Hoeji
2010 Volume.54 No. 5 p.334 ~ p.340
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Effects of Histidine Polymers on Mucin Release from Primary Cultured Airway Epithelial Cells
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Jeon Byeong-Kyou
Yoon In-Dae
Lee Jae-Woo
Lee Choong-Jae
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Abstract
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We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with $glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on -mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.
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KEYWORD
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airway mucin, HTSE cells, poly-L-histidine
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